Access the power and flexibility of the baculovirus recombinant platform and its posttranslational pathways including:
- signal peptide cleavage
- proteolytic cleavage
- N- and O-glycosylation
- acylation
- amidation
- phosphorylation
- prenylation
- carboxymethylation
- disulfide bridge formation
- oligomerization/supramolecular assembly
- subcellular localization
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- Speed – we can move from baculovirus to partially purified bulk in less than 4 weeks*, and can implement simultaneous screening of multiple constructs for faster optimization of expression
- Scalability – our in vivo bioreactor system enables linear scalability with minimal protein-specific optimization compared to traditional production methods
- Safety – mammalian viruses and prions cannot be propagated by insect larvae, eliminating a concern with traditional culture production
- BEVS – we offer the full flexibility of the baculovirus recombinant platform and its post-translational pathways, optimized for our in vivo production system, and at lower cost than cell-based production
* A typical project time line, from receipt of DNA to purified bulk, is approximately 12 weeks. The actual project length is dependent upon customer requirements and amount of vector optimization required.
Our high expression in vivo baculovirus system has:
- Automated processing
- Rigorous process control
- Pre-occluded baculovirus technology
- Linearly scalability with minimal protein-specific optimization
- High yield – we often get superior recovery of functional proteins that elude traditional systems
- Produced proteins of consistent quality and purity from milligram to gram quantities and due to the linearly scalability of our production system we can produce larger quantities of protein using our existing process
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